Table 3.

Broth dilution MICs of cationic peptides against various gram-negative bacteria

SpeciesStrainRelevant phenotype or genotypeMIC (μg/ml)
CP26CP29CP201CP208CEMECEMA
P. aeruginosaPAO1Wild type2286422
K385nfxB4486422
1008OCR01nalB221612822
PAO963nalA22812822
PA-83-48β-Lactamase derepressed4232>12824
Z61Antibiotic sensitive223212824
E. coliUB1005Wild type0.50.543211
S. typhimurium14028sParent of MS7953s2232>6424
MS7953sDefensin sensitive0.50.252811