Table 3.

MICs of cephalosporins and carbapenems alone and combined with clavulanic acid or BRL 42715 for K. pneumoniaestrains producing different β-lactamases

StrainEnzymeMIC (μg/ml) with the indicated inhibitora:
CAZFEPPIRFOXIMPMEM
NICLANICLANICLANICLABRLNICLABRLNICLABRL
143098-3SHV-5b >256≤0.5128ND128ND646464211222
C1No ESBL2≤0.511≤0.51128646410.50.5112
C1-T6TEM-6>256≤0.532164112864ND11ND11ND
C1-T10TEM-101281823246464ND10.5ND21ND
C1-T12TEM-12>25686411282128128ND11ND11ND
C1-T26TEM-26>256≤0.5161322128128ND11ND11ND
C1-S2SHV-2>256≤0.5>2561625616128128ND44ND44ND
C1-S3SHV-3>256816216212864ND21ND21ND
C1-S5SHV-5>256≤0.512821284646464211222
C1-AC233AmpC646410.542>1,024>1,02464643211682
C1-AC245AmpC12812810.542>1,024>1,02464643241682
C1-AC248AmpC128642184>1,024>1,02412832162442
C1-AC252AmpC25612821168>1,024>1,02464110.5242
NEDH-1SHV-2>2562>256ND>256ND64646420.51221
C2Cured≤0.5≤0.5≤0.5≤0.5≤0.5≤0.564323210.50.50.250.50.5
C2-S2SHV-2>2564>256≤0.5>25626432ND21ND10.5ND
  • a Abbreviations: CAZ, ceftazidime; PIM, cefepime; PIR, cefpirome; FOX, cefoxitin; IPM, imipenem; MEM, meropenem; CLA, clavulanic acid; BRL, BRL 42715; NI, no inhibitor; ND, not determined.

  • b Presumptive identification based on pI determination.