Table 2.

Effects of selected compounds on the activity of different azoles against two strains of C. albicans

Compound (concentration)AzoleStrainIC50a(μg/ml)Fold increase in IC50Maximum fold increase in cell number
NoneFluconazole244330.501.01.0
0.21b1.01.0
900280.601.01.0
Itraconazole244330.00471.01.0
900280.00291.01.0
Ketoconazole244330.00251.01.0
900280.00191.01.0
AlbendazoleFluconazole244330.951.99.5
 (2 μg/ml)0.48b2.318
900280.981.69.0
Itraconazole244330.0183.84.5
900280.0155.216
Ketoconazole244330.0228.86.5
900280.00573.019
SulfadiazineFluconazole244330.751.54.9
 (50 μg/ml)0.36b1.73.3
900280.631.19.0
Itraconazole244330.0102.178
900280.00722.56.2
Ketoconazole244330.00251.02.9
900280.00251.35.2
Fluphenazine (20 μg/ml)Fluconazole244331.32.615
1.3b6.240
900281.83.045
Itraconazole244330.0122.620
900280.00863.011
Ketoconazole244330.0187.220
900280.0136.849
IsoniazidFluconazole244330.390.80.9
 (5 μg/ml)900280.500.81.3
Itraconazole244330.00491.01.2
900280.00200.71.7
Ketoconazole244330.00301.21.5
900280.00170.90.8
  • a Unless otherwise noted, values were obtained after an 18-h incubation in YPD medium with shaking at 30°C.

  • b Values are data obtained in RPMI 1640 medium at 48 h.