Table 3.

Lung and kidney tissue burdensa

TissueDrug or treatmentDose (mg/kg)Mean burden95% CINo. of mice with counts of <20 CFU/g
LowerUpper
KidneyControlNone2.3 × 1071.2 × 1075.7 × 1070
GM3104.8 × 104 b2.5 × 1041.2 × 1050
58.0 × 105 b4.3 × 1052.0 × 1060
1.251.3 × 1086.9 × 1073.2 × 1080
Amphotericin B2.52.3 × 102 c1.2 × 1025.7 × 1023
Fluconazole53.4 × 106 b1.8 × 1068.3 × 1060
LungControlNone5.9 × 1073.1 × 1071.6 × 1081
GM3101.1 × 105 b5.7 × 1042.6 × 1050
52.9 × 106 b1.5 × 1067.8 × 1061
1.251.9 × 1081.0 × 1084.8 × 1080
Amphotericin B2.51.2 × 102 c6.7 × 1013.1 × 1026
Fluconazole51.3 × 107 b6.8 × 1063.1 × 1070
  • a Values are expressed as CFU per gram of tissue. Each treatment group consisted of seven mice. CI, confidence interval.

  • b P < 0.05 compared with control group.

  • c P < 0.01 compared with control group or groups receiving fluconazole or GM3.