Table 1.

Relative fitness of induced H37Rv rifampin-resistant mutant alleles

SSCP patternNo. of replicatesMean no. of generations of H37RvLocation of mutationRelative fitness
SensitiveResistant
A1 48.656.95His526→Tyr0.80
A2 45.902.80His526→Tyr0.78
A3 36.734.62His526→Asp0.42
B1 57.888.30Ser531→Leu1.05
B2 37.737.43Ser531→Leu0.93
B3 36.836.29Ser531→Leu0.89
B4 39.604.83Ser531→Leu0.50
C1 25.6810.04His526→Arg0.56
C2 56.401.35His526→Arg0.21