Table 1.

Pharmacokinetic parameters for serum and interstitial space fluid of inflamed diabetic foot lesions and unaffected subcutaneous adipose tissue following administration of ciprofloxacin to patients with non-insulin-dependent diabetes mellitusa

SampleMean ± SDb
CmaxTmaxAUC0–∞, AUC0–300
Serum2.83 ± 1.2123 ± 8527 ± 318, 253 ± 102
Diabetic ulcer2.18 ± 1.1330 ± 11278 ± 182, 209 ± 121
Healthy subcutis2.12 ± 0.5523 ± 8317 ± 207, 199 ± 75
  • a Patients (n = 6) were given a single 200-mg dose i.v. over 20 min.

  • b Cmax (micrograms/milliliter), maximum concentration of drug in serum; Tmax(minutes), time to maximum concentration of drug in serum; AUC0–∞ (micrograms · minute/milliliter), area under the concentration-time curve from 0 h to infinity.