TABLE 5

Antifungal effects of PC945 and known antifungal agents on four itraconazole-susceptible A. fumigatus strains, as determined using CLSI methodology

Test agentMIC (μg/ml)a,cMIC50 (μg/ml)b,c
MedianInterquartile rangeMedianInterquartile range
PC9450.031*0.020–0.0310.011**0.0083–0.024
Voriconazole0.50.5–0.50.140.082–0.15
Posaconazole0.0470.031–6.00.0150.0095–0.016
  • a Determined visually.

  • b Determined using optical density measurements.

  • c *, P < 0.05; **, P < 0.01 for PC945 versus the results for voriconazole (Kruskal-Wallis one-way ANOVA with Dunn's test).