Table 3.

AUC and AUC/MIC ratio for total LY and free LY

Dose (mg/kg)Mean AUC0–24 (μg · h/ml) for total drugAUC/MIC for total drugAUC (μg · h/ml) for free drug corrected for 75% plasma protein bindingAUC/MIC for free drug assuming 75% plasma protein bindingAUC for free drug corrected for 95% plasma protein bindingAUC/MIC ratio for free drug assuming 95% plasma protein binding
0.10.56537.60.14120.030.5
0.251.561040.39260.085.3
0.53.472310.87580.1711.3
1.010.066712.51670.5033.3