Table 1.

Noncompartmental pharmacokinetics in plasma after administration of a single dose of LY to healthy rabbitsa

Drug dose (mg/kg)Cmax(μg/ml)bCmin (at 24 h) (μg/ml)AUC0–4 (μg · h/ml)cAUC0–24 (μg · h/ml)V (liters)CL (liter/h)t1/2 (h)
0.100.464 ± 0.082<LOQd0.469 ± 0.0300.565 ± 0.0371.9 ± 0.130.432 ± 0.033.0 ± 0.11
0.251.298 ± 0.425<LOQ1.168 ± 0.1091.559 ± 0.0752.1 ± 0.150.375 ± 0.023.9 ± 0.23
0.501.488 ± 0.083<LOQ1.961 ± 0.1533.474 ± 0.3382.7 ± 0.160.387 ± 0.034.8 ± 0.33
1.003.563 ± 0.6440.044 ± 0.0224.577 ± 0.21710.064 ± 0.7862.3 ± 0.180.281 ± 0.025.8 ± 0.65
  • a All values are given as means ± SEM for three rabbits at each dose.

  • b P < 0.05 by Kruskal-Wallis nonparametric ANOVA.

  • c P = 0.917 by ANOVA for departure from linearity after dose normalization.

  • d <LOQ, less than the lower limit of quantitation.