Table 2.

Class A β-lactamases included in phylogenetic analysis

EnzymeOrganismAccession no. (databasea)% IdentitybBLAST scorescReference or source
CME-1 Chryseobacterium meningosepticum CCUG 4310 AJ006275 (EM)This study
VEB-1d Escherichia coliMG-1 AF078527 (EM)46587 34
CblA Bacteroides uniformisWAL-7088 P30898 (SW)40547 42
CepA Bacteroides fragilisCS30 L13472 (EM)36492 36
PER-1 Pseudomonas aeruginosaRNL-1 P37321 (SW)39486 30
PER-2 Salmonella enterica serotype Typhimurium JMC X93314 (EM)38486 6
CfxA Bacteroides vulgatusCLA341 P30899 (SW)29328 32
BRO-1 Moraxella catarrhalis ATCC 53879 Q59514 (SW)27236 8
PSE-1 Pseudomonas aeruginosaRPL11 Q03170 (SW)23198 20
ULA27 Citrobacter diversusULA27 P22390 (SW)25184 33
L2 Stenotrophomonas maltophilia 1275 IID P96465 (SW)24176 49
NMC-A Enterobacter cloacaeNOR-1 P52663 (SW)24169 27
SHV-1 Escherichia coliP453 P14557 (SW)23164 5
TEM-1 Salmonella enterica serotype Paratyphi R7268 P00810 (SW)23162 43
Sme-1 Serratia marcescensS6 P52682 (SW)21145 28
MEN-1 Escherichia coliMEN P28585 (SW)22144 4
OXY-2 Klebsiella oxytocaD488 P23954 (SW)21138 35
PenA Burkholderia cepacia249 U85041 (EM)22135 45
BlaI Yersinia enterocoliticaY-56 Q01166 (SW)22133 41
  • a EM, EMBL/GenBank nucleotide sequence database; SW SwissProt protein sequence database.

  • b Compared to the sequence of the mature CME-1 protein and calculated on the basis of the multiple alignment used for phylogenetic analysis.

  • c These scores were returned after submission of the 295-amino-acid polypeptide encoded by theblaA CME ORF as a query at the BLAST network service using WU-BLAST server version 2.0a13.

  • d The sequence of VEB-1 is identical to that of CEF-1, which is encoded by a gene found in a P. aeruginosaintegron (46).