Table 2.

Effects of LY, AmB, and FLU on serum creatinine and serum potassium concentrations in persistently neutropenic rabbits with disseminated candidiasis

Treatment group (no. of animals)Serum creatinine concn (mg/dl)aSerum potassium concn (meq/liter)a
UC (n = 13)1.70 ± 0.263.88 ± 0.11
LY (n = 30)b1.30 ± 0.023.98 ± 0.10
AmB (n = 6)5.60 ± 1.42c3.02 ± 0.23d
FLU (n = 6)1.20 ± 0.094.15 ± 0.18
  • a All values are expressed as means ± SEMs.

  • b Mean serum creatinine and serum potassium concentrations for all dosage groups.

  • c P < 0.001 (ANOVA with Bonferroni’s correction for multiple comparisons).

  • d P < 0.01 (ANOVA with Bonferroni’s correction for multiple comparisons).