TABLE 3

Antifungal effects of PC945 and known antifungal agents in azole-susceptible and azole-resistant strains of A. fumigatusa

StrainResistance mechanismIC50 (IC90) (μg/ml) of indicated agent
PC945VoriconazolePosaconazoleItraconazoleAmphotericin BCaspofungin
NCPF2010None0.0084 (0.010)0.16 (0.20)0.0086 (0.014)0.057 (0.085)0.23 (0.48)0.11 (>1)
AF294None0.0020 (0.0043)0.082 (0.27)0.0056 (0.011)0.041 (0.052)0.21 (0.79)>1 (>1)
AF293None0.0012 (0.0041)0.25 (0.74)0.010 (0.028)0.032 (0.23)0.24 (0.85)>1 (>1)
AF72G54E mutation0.0061 (0.029)0.019 (0.062)0.032 (0.19)0.43 (>1)0.18 (0.64)0.10 (>1)
AF91M220V mutation0.0081 (0.059)0.12 (0.38)0.024 (0.12)0.26 (>1)0.42 (>1)0.072 (>1)
TR34/L98HTR34/L98H mutation0.034 (>1)>1 (>1)0.086 (0.13)0.22 (>1)0.14 (0.29)0.082 (>1)
  • a IC50 and IC90 values were determined from optical density measurements.