TABLE 3

Factors influencing drug concentrationsa

Type of analysis and factorRMPINHPZA
β95% CIP valueβ95% CIP valueβ95% CIP value
Univariate analysis
    Gender−0.334−0.664 to −0.0050.047−0.311−0.746 to 0.1230.160−2.779−4.115 to −1.442<0.001
    Age0.0150.004 to 0.0270.0070.0360.022 to 0.051<0.0010.0520.006 to 0.0980.026
    Smoker−0.083−0.414 to 0.2480.6210.294−0.142 to 0.7300.186−0.298−1.646 to 1.0500.664
    Alcohol user−0.175−0.492 to 0.1420.2790.175−0.242 to 0.5930.411−0.071−1.362 to 1.2190.914
    Smear status−0.150−0.514 to 0.2140.4200.141−0.349 to 0.6300.573−0.426−1.925 to 1.0740.578
    Diabetes mellitus−0.092−0.456 to 0.2710.619−0.960−1.437 to −0.483<0.001−3.255−4.727 to −1.783<0.001
    Body wt−0.016−0.029 to −0.0020.025−0.074−0.102 to −0.067<0.001−0.281−0.335 to −0.227<0.001
    Baseline INH susceptibilitybNANANA0.699−0.584 to 1.9820.285NANANA
    Type of TB0.002−0.322 to 0.3250.9920.7890.364 to 1.215<0.0011.6680.353 to 2.9840.013
    Category of ATT0.080−0.375 to 0.5360.7300.024−0.577 to 0.6250.938−1.150−3.004 to 0.7050.224
    Drug dose0.1750.078 to 0.271<0.0010.3980.322 to 0.473<0.0010.5200.428 to 0.613<0.001
Multivariate analysis
    Gender−0.442−0.782 to −0.1020.011NANANA−3.161−4.499 to −1.823<0.001
    Age0.0200.009 to 0.032<0.0010.0510.036 to 0.066<0.0010.1220.073 to 0.170<0.001
    Diabetes mellitusNANANA−1.006−1.511 to −0.501<0.001−2.676−4.233 to −1.1190.001
    Body wtNSNSNSNSNSNSNSNSNS
    Type of TBNANANANSNSNSNSNSNS
    Drug dose0.1710.075 to 0.268<0.0010.3750.298 to 0.451<0.0010.4820.387 to 0.576<0.001
  • a NS, not significant; NA, not applicable; β, regression coefficient, which indicates the change per 1 unit.

  • b This factor was tested against INH concentrations only.