Table 2.

Trough cefepime levels and creatinine clearance measured after multiple 2-g doses of cefepime over 12 h (profile B), and trough plasma cefepime concentrations at 48 h predicted by simulated dosing regimens

PatientCLCR (ml/min)C0h (μg/ml)C12 h (μg/ml)C48 h trougha (μg/ml)
6 g/dayb1 g/4 hc
2128.42.62.129.89.6
387.65.44.052.929.5
5127.2<1.0<1.028.27.4
6195.61.4<1.024.910.0
7137.43.02.830.113.5
9146.4<1.0<1.032.113.0
10115.82.02.235.713.2
11118.8<1.0<1.042.224.1
12150.61.41.424.310.9
1374.46.27.753.033.6
Median127.81.71.831.113.1
Mean128.235.316.5
SD30.59.78.3
  • a Predicted minimum cefepime concentration after 48 h.

  • b Simulated continuous infusion of 6 g of cefepime per 24 h with an initial 0.5-g loading dose.

  • c Simulated 3-min infusion of 1 g of cefepime every 4 h.