Table 1.

Risk factors for ciprofloxacin-resistant E. coli bacteremia (univariate analysis)

CharacteristicPatients infected with ciprofloxacin-susceptible strains (n = 502)Patients infected with ciprofloxacin-resistant strains (n = 70)OR (95% CIa)P
Age (yr [mean ± SDb])65.8 ± 18.470.2 ± 130.015
Sex (no. of males/no. of females)264/23844/260.10
No. (%) of patients with:
 underlying disease164 (33)61 (87)3.2 (2–7)0.001
 Source of acquisition
  Community407 (81)39 (56)
  Nosocomial95 (19)31 (44)3.4 (2–6)<0.001
 Source of infection
  Urinary tract312 (62)32 (46)0.5 (0.3–0.8)0.009
  Intra-abdominal135 (26)17 (24)NSc
  Unknown42 (8)19 (27)4 (2–8)<0.001
 Urinary catheter68 (14)28 (40)4.3 (2.5–7.7)<0.001
 Prior antibiotic use41 (8)36 (51)11.9 (7–25)<0.001
 Prior quinolone use6 (1)25 (36)46 (17–117)<0.001
 Mortality53 (11)20 (23)3.3 (2–6)<0.001
  • a CI, confidence interval.

  • b SD, standard deviation.

  • c NS, not significant.