Table 2.

Pharmacokinetic parameters of oral moxifloxacin (Bay 12-8039) obtained with a dosage of 400 mg once daily for 10 daysa

DayCmax (mg/liter)Cmax,norm [kg · h/liter]Tmax(h)AUC0–∞ (kg · h/liter)AUC0–∞,norm [mg · h/liter]AUC0–24 (kg · h/liter)AUC0–24,norm [mg · h/liter]t1/2(h)b
1 3.36 (21.5)0.63 (28.4)1.49 (62.2)36.68 (13.2)6.81 (12.4)30.24 (14.2)5.66 (10.5)9.30 (12.1)
104.52 (12.2)0.85 (18.8)1.24 (48.0)47.97 (5.8)8.98 (16.9)11.95 (10.8)
  • a Values are geometric means, with percent CVs in parentheses.

  • b t 1/2, half-life.