Table 6.

pI and kinetic parameters for ESBL-type β-lactamases

DrugKinetic parameters for the following strains (enzymes; pIs):
CF249 (TEM-24; 6.5)CF39 (TEM-3; 6.3)CF669 (TEM-66; 6.0)
VmaxaKm (μM)VmaxKm (μM)VmaxKm (μM)
Benzylpenicillin100510041005
Amoxicillin6243725705
Cephalothin281431072211030
Cefotaxime13050445100400100
Ceftazidime1,4103774040040450
  • a V max values are given as a percentage of the V max for benzylpenicillin, which was taken as 100%.