Table 2.

MICs of cephalosporins forS. pneumoniae isolates

Antimicrobial agent (no. of strains)% (cumulative %) of strains for which the MIC (μg/ml) is as follows:
≤0.030.060.120.250.512481632≥64
Ceftriaxone (1,274)63.6 (63.6)7.1 (70.7)3.6 (74.3)4.4 (78.7)6.3 (85.0) 10.8 (95.8) a 2.8 (98.6)1.3 (99.9)0.1 (99.9)0.0 (99.9)0.0 (99.9)0.1 (100.0)b
Cefotaxime (1,276)59.7 (59.7)7.3 (67.0)5.5 (72.5)5.4 (77.9)9.2 (87.1) 9.5 (96.6) 1.9 (98.5)0.6 (99.1)0.8 (99.9)0.0 (99.9)0.1 (100.0)b
Cefpodoxime (1,274)53.9 (53.9)6.8 (60.7)6.6 (67.3)3.8 (71.1)3.1 (74.3)4.7 (79.0) 14.7 (93.6) 3.0 (96.6)1.4 (98.0)1.7 (99.8)0.2 (99.9)0.1 (100.0)
Cefuroxime (1,275)25.1 (25.1)2.1 (27.2)1.8 (29.0)13.1 (42.1)23.9 (66.0)14.2 (80.2)8.6 (88.8) 7.2 (96.0) 2.4 (98.4)0.8 (99.2)0.7 (99.9)0.1 (100.0)c
Cephalothin (1,276)0.1 (0.1)4.3 (4.4)45.0 (49.4)11.4 (60.7)10.9 (71.6)3.7 (75.3)3.8 (79.1)5.6 (84.7) 7.6 (92.3) 5.3 (97.6)1.8 (99.4)0.6 (100.0)
Cefprozil (1,274)0.3 (0.3)11.9 (12.2)23.2 (35.3)21.6 (56.9)11.5 (68.4)4.6 (72.9)4.2 (77.1)5.3 (82.4) 10.0 (92.4) 4.4 (96.8)2.7 (99.5)0.5 (100.0)
Ceftibuten (1,275)0.4 (0.4)d 0.5 (0.9)0.7 (1.6)8.6 (10.3)40.1 (50.4)9.3 (59.6) 40.4 (100.0) e
Cefixime (1,275)54.1 (54.1)d 7.8 (62.0)4.6 (66.6)3.8 (70.4)3.5 (73.9)3.4 (77.3) 22.7 (100.0) e
Cefaclor (1,275)0.1 (0.1)0.2 (0.2)0.9 (1.2)27.2 (28.4)25.6 (54.0)14.5 (68.5)4.2 (72.8)1.8 (74.6)1.6 (76.2)1.5 (77.7)3.1 (80.9) 19.1 (100.0)
Loracarbef (1,273)0.1 (0.1)0.2 (0.2)1.0 (1.3)22.5 (23.7)32.0 (55.7)14.8 (70.5)2.7 (73.3)2.0 (75.3)0.8 (76.0)2.0 (78.0) 22.0 (100.0)
  • a Values in boldface indicate percentage (cumulative percentage) of strains for which the MIC is the MIC90.

  • b The MICs of ceftriaxone and cefotaxime for one strain were >4 μg/ml.

  • c The MIC of cefuroxime for one strain was ≥64 μg/ml.

  • d The lowest concentration tested was 0.25 μg/ml.

  • e The highest concentration tested was 16 μg/ml.