Table 1.

Strains tested in this study and their previously publisheda resistance mechanisms

PatientIsolateEfflux pumpb expression levelERG11 point mutation(s)
IC23S405F heterozygote
IC32No increase relative to C23No data
IC39Increased CDR1 and CDR2 signals relative to C23S405F homozygote
IIC45
IIC18No increase relative to C45
IIC46No increase relative to C45
IIIC33
IIIC34No increase relative to C33S405F homozygote
IIIC26Increased CDR1 and CDR2 signals relative to C33S405F and Y132H homozygote
IIIC82Less pronounced increase in CDR1 and CDR2 signals relative to C33S405F homozygote
IVC27
IVC37No increase relative to C27G464S and R467K homozygote
IVC40Increased CaMDR1 signal relative to C27G464S and R467K homozygote, Y132H heterozygote
VC43G129A heterozygote
VC48Increased CDR1 and CDR2 signals relative to C43No data
VC56Increased CDR1and CDR2 signals relative to C43G129A and G464S homozygote
  • a References 27 and29 to 31.

  • b CDR1, CDR2, andCaMDR1.