Table 5.

Sterol compositions of C. albicans isolates

Sterol(s)Avg % of [14C]acetate incorporation into total sterolsa
C43C48C56
Control0.03 μM itraconazoleControl0.3 μM itraconazoleControl0.3 μM itraconazole
Ergosterol89.20.660.410.473.717.3
3,6-Diol2.551.430.733.121.127.2
Eburicol, lanosterol5.418.94.720.93.216
Obtusifoliol1.7131.713.91.315.3
14α-Methyl-fecosterol1.72.7
14α-Methyl-ergosta-5,7,22,24(28)-tetraene-3βol12.76.61.3
Obtusifolione13.515120
  • a Results shown are averages of at least three independent experiments. The itraconazole IC50s for ergosterol synthesis were 0.002, 0.05, and 0.04 μM in strains C43, C48, and C56, respectively.