Table 4.

pIs and kinetic parameters inhibitors for TEM-type and IRT-type β-lactamases

DrugKinetic parameters for the following strains (enzymes; pIs):
CF19 (TEM-1; 5.4)CF29 (TEM-2; 5.6)CF579 (TEM-57; 5.2)CF739 (TEM-73 [IRT-18]; 5.2)CF749 (TEM-74 [IRT-19]; 5.2)CF449 (TEM-44 [IRT-13]; 5.4)CF659 (TEM-65 [IRT-16]; 5.4)
VmaxaKm (μM)VmaxKm (μM)VmaxKm (μM)VmaxKm (μM)VmaxKm (μM)VmaxKm (μM)VmaxKm (μM)
Benzylpenicillin100251002010040100334100330100375100350
Amoxicillin772695257338207315140400145360150400
Ticarcillin10101091015281027652.34602600
Cephalothin1025025500179001.51,000130023122400
  • a V max values are given as a percentage of the V max for benzylpenicillin, which was taken as 100%.