Table 3.

MICs of fluoroquinolones and macrolides for S. pneumoniae

Antimicrobial class and agent (no. of strains)% (cumulative %) of strains for which the MIC (μg/ml) is as follows:
≤0.030.060.120.250.512481632≥64
Fluoroquinolones
 Grepafloxacin (1,275)0.5 (0.5)14.4 (14.9)71.8 (86.7) 12.3 (99.0) a 0.8 (99.8)0.1 (99.8)0.1 (99.8)0.1 (99.9)0.1 (100)
 Sparfloxacin (1,276)0.1 (0.1)0.5 (0.6)17.6 (18.2) 75.7 (93.9) 5.6 (99.5)0.2 (99.7)0.2 (99.9)0.0 (99.9)0.0 (99.9)0.1 (100.0)
 Levofloxacin (1,274)0.1 (0.1)0.0 (0.1)0.1 (0.2)0.2 (0.4)65.4 (65.8) 33.6 (99.4) 0.4 (99.8)0.1 (99.9)0.1 (99.99)0.1 (100.0)
 Ciprofloxacin (1,275)0.1 (0.1)0.0 (0.1)0.4 (0.5)10.1 (10.6)61.3 (71.9) 24.6 (96.5) 3.0 (99.5)0.3 (99.8)0.0 (99.8)0.2 (100.0)
 Ofloxacin (1,275)0.2 (0.2)0.1 (0.3)0.1 (0.4)0.2 (0.6)0.8 (1.4)79.7 (81.1) 18.5 (99.6) 0.2 (99.8)0.0 (99.8)0.2 (100.0)
Macrolides
 Erythromycin (1,276)27.3 (27.3)46.8 (74.1)2.0 (76.1)0.3 (76.4)0.3 (76.7)0.7 (77.4)1.7 (79.1)5.8 (84.9) 5.5 (90.4) 3.8 (94.2)0.4 (94.6)5.4 (100.0)
 Clarithromycin (1,275)69.6 (69.6)6.3 (75.9)0.5 (76.4)0.3 (76.7)0.5 (77.2)1.5 (78.7)5.5 (84.2)4.8 (89.0) 4.6 (93.6) 1.2 (94.8)0.3 (95.1)4.9 (100.0)
 Azithromycin (1,275)7.2 (7.2)58.6 (65.8)10.9 (76.7)0.3 (77.0)0.2 (77.2)1.0 (78.2)2.2 (80.4)5.5 (85.9) 4.8 (90.7) 3.1 (93.8)6.2 (100.0)
  • a Values in boldface indicate percentage (cumulative percentage) of strains for which the MIC is the MIC90.