Table 3.

Fluconazole accumulation and inhibition of ergosterol biosynthesis by fluconazole in C. glabrata isolates

IsolateAmt of [3H]fluconazole/2 × 107 cells (cpm)IC50 of fluconazole for ergosterol biosynthesis (nM)
DSY528300 ± 2055 ± 10
DSY53095 ± 2065 ± 8
DSY562313 ± 2240 ± 12
DSY56581 ± 550 ± 8
DSY1041457 ± 7NDa
  • a ND, not determined.