TABLE 8

In vivo activities of PC945 and posaconazole

Test agentDose (μg/mouse)No. of survivors on day 7/total no. of mice (%)Median days of survivalLog rank (Mantel-Cox test) P valuea
Vehicle3/16 (19)5
PC9450.564/8 (50)60.14
2.85/8 (63)6.50.022*
1410/16 (63)Undefined0.0095**
Posaconazole2.81/8 (13)50.69
147/16 (44)60.050*
706/8 (75)Undefined0.0028**
  • a *, P < 0.05; **, P < 0.01.