Table 2.

Pharmacokinetic parameters

PatientCLCR (ml/min)AUC0–∞ (μg · h/ml)VSS (liters/ kg ABW)t1/2α(h)t1/2β (h)CLT (liters/h)CLR (liters/h)24-h urinary excretion (%)
11821350.370.392.814.012.590
21221960.360.192.210.09.495
31891930.330.371.99.28.296
41911630.480.453.311.19.482
51252580.380.101.96.96.799
61392510.310.632.27.27.8107
71642230.430.294.08.48.498
81042940.430.353.06.35.890
91502660.55NCa 2.57.06.388
10NAb 3330.340.282.85.6NANA
111841570.500.313.511.39.382
121302150.660.273.18.85.763
Mean (SD)135 (31)224 (59)0.43 (0.10)0.33 (0.14)2.8 (0.6)8.8 (2.4)8.1 (2.0)90 (12)
  • a NC, not calculated for this patient.

  • b NA, urine data not available for this patient.