TABLE 2

Pharmacokinetic parameter estimates

ParameteraMean (SD)b
Model 1 (16)Model 2 (6)Model 3 (18)Model 4 (this study)
Vc18.25 (8.88)14.80 (7.90)0.21 (0.042)25.76 (11.68)
k122.36 (4.23)1.13 (0.78)1.12 (0.224)2.29 (2.42)
k212.72 (7.08)0.66 (0.94)0.48 (0.096)1.44 (1.73)
keNA0.30 (0.19)NANA
CLINT0.48 (0.30)NA0.05 (0.010)0.18 (0.043)
CLSLOPE0.83 (0.67)NA0.75 (0.2475)0.60 (0.33)
  • a V, volume of the central compartment (liters for models 1, 2, and 4; liters/kg for model 3); CLINT clearance due to nonrenal means (liters/h); CLSLOPE, clearance due to creatinine clearance (liters/h); k12, transfer rate constant from the central compartment to the peripheral compartment (per hour); k21, transfer rate constant from the peripheral compartment to the central compartment (per hour); ke, elimination constant from the central compartment (per hour). NA, not applicable.

  • b Source references are indicated parenthetically in the subheadings for each of the four models.