TABLE 1

Antimicrobial activity of omadacycline against the main organisms and organism groups of isolates studied

Organism/organism group (no. of isolates)No. (cumulative %) of isolates at MIC (μg/ml) of:MIC50MIC90
0.0150.030.060.120.250.512481632>32
Staphylococcus aureus (18,577)4 (<0.1)100 (0.6)1754 (10.0)11833 (73.7)3821 (94.3)707 (98.1)235 (99.3)106 (99.9)17 (100.0)0.120.25
    MSSA (10,836)3 (<0.1)71 (0.7)1106 (10.9)7099 (76.4)2170 (96.4)356 (99.7)24 (99.9)7 (100.0)0.120.25
    MRSA (7,741)1 (<0.1)29 (0.4)648 (8.8)4734 (69.9)1651 (91.2)351 (95.8)211 (98.5)99 (99.8)17 (100.0)0.120.25
CoNS (2,992)17 (0.6)121 (4.6)751 (29.7)589 (49.4)385 (62.3)771 (88.0)339 (99.4)19 (100.0)0.251
    MS-CoNS (837)9 (1.1)65 (8.8)291 (43.6)206 (68.2)89 (78.9)121 (93.3)54 (99.8)2 (100.0)0.120.5
    MR-CoNS (2,155)8 (0.4)56 (3.0)460 (24.3)383 (42.1)296 (55.8)650 (86.0)285 (99.2)17 (100.0)0.251
Enterococcus spp. (5,519)32 (0.6)564 (10.8)2189 (50.5)1594 (79.3)856 (94.9)251 (99.4)30 (99.9)2 (>99.9)1 (100.0)0.060.25
    Vancomycin susceptible (4,456)24 (0.5)437 (10.3)1668 (47.8)1331 (77.6)755 (94.6)221 (99.6)17 (99.9)2 (>99.9)1 (100.0)0.120.25
    Vancomycin nonsusceptible (1,063)8 (0.8)127 (12.7)521 (61.7)263 (86.5)101 (96.0)30 (98.8)13 (100.0)0.060.25
Enterococcus faecalis (3,346)21 (0.6)266 (8.6)1032 (39.4)1097 (72.2)697 (93.0)212 (99.4)18 (99.9)2 (>99.9)1 (100.0)0.120.25
    Vancomycin susceptible (3,254)17 (0.5)260 (8.5)1010 (39.6)1061 (72.2)680 (93.1)207 (99.4)16 (99.9)2 (>99.9)1 (100.0)0.120.25
    Vancomycin nonsusceptible (92)4 (4.3)6 (10.9)22 (34.8)36 (73.9)17 (92.4)5 (97.8)2 (100.0)0.120.25
Enterococcus faecium (1,955)8 (0.4)269 (14.2)1053 (68.0)434 (90.2)143 (97.5)36 (99.4)12 (100.0)0.060.12
    Vancomycin susceptible (1,019)5 (0.5)149 (15.1)571 (71.1)217 (92.4)64 (98.7)12 (99.9)1 (100.0)0.060.12
    Vancomycin nonsusceptible (936)3 (0.3)120 (13.1)482 (64.6)217 (87.8)79 (96.3)24 (98.8)11 (100.0)0.060.25
Other Enterococcus spp. (218)3 (1.4)29 (14.7)104 (62.4)63 (91.3)16 (98.6)3 (100.0)0.060.12
Streptococcus pneumoniae (6,253)209 (3.3)2402 (41.8)3105 (91.4)426 (98.2)88 (99.6)23 (100.0)0.060.06
    Penicillin susceptible (≤0.06) (3,747)157 (4.2)1573 (46.2)1724 (92.2)237 (98.5)46 (99.7)10 (100.0)0.060.06
    Penicillin intermediate (≥0.12 and ≤1) (1,040)30 (2.9)392 (40.6)541 (92.6)64 (98.8)11 (99.8)2 (100.0)0.060.06
    Penicillin resistant (≥2) (1,466)22 (1.5)437 (31.3)840 (88.6)125 (97.1)31 (99.2)11 (100.0)0.060.12
Viridans group streptococci (1,538)85 (5.5)528 (39.9)629 (80.8)235 (96.0)55 (99.6)6 (100.0)0.060.12
Beta-hemolytic streptococci (3,196)8 (0.3)740 (23.4)1695 (76.4)694 (98.2)52 (99.8)7 (100.0)0.060.12
    Streptococcus pyogenes (1,576)3 (0.2)547 (34.9)898 (91.9)114 (99.1)11 (99.8)3 (100.0)0.060.06
    Streptococcus agalactiae (1,570)5 (0.3)186 (12.2)776 (61.6)567 (97.7)34 (99.9)2 (100.0)0.060.12
    Other beta-hemolytic streptococci (50)0 (0.0)7 (14.0)21 (56.0)13 (82.0)7 (96.0)2 (100.0)0.060.25
Enterobacteriaceae (20,305)0 (0.0)1 (<0.1)17 (0.1)582 (3.0)4052 (22.9)4840 (46.7)5403 (73.4)2638 (86.3)1191 (92.2)846 (96.4)511 (98.9)224 (100.0)28
Escherichia coli (8,519)0 (0.0)15 (0.2)561 (6.8)3708 (50.3)2612 (80.9)1167 (94.6)376 (99.1)69 (99.9)9 (>99.9)2 (100.0)0.52
    ESBL-negative Escherichia coli (6,572)0 (0.0)10 (0.2)495 (7.7)3171 (55.9)1938 (85.4)713 (96.3)205 (99.4)35 (99.9)4 (>99.9)1 (100.0)0.52
    ESBL SP phenotype Escherichia coli (1,947)0 (0.0)5 (0.3)66 (3.6)537 (31.2)674 (65.8)454 (89.2)171 (97.9)34 (99.7)5 (99.9)1 (100.0)14
Klebsiella pneumoniae (4,181)0 (0.0)1 (<0.1)11 (0.3)80 (2.2)967 (25.3)1908 (71.0)648 (86.5)310 (93.9)159 (97.7)66 (99.3)31 (100.0)28
    ESBL-negative Klebsiella pneumoniae (2,706)0 (0.0)1 (<0.1)5 (0.2)59 (2.4)743 (29.9)1385 (81.0)297 (92.0)106 (95.9)76 (98.7)26 (99.7)8 (100.0)24
    ESBL SP phenotype Klebsiella pneumoniae (1,475)0 (0.0)6 (0.4)21 (1.8)224 (17.0)523 (52.5)351 (76.3)204 (90.1)83 (95.7)40 (98.4)23 (100.0)28
Klebsiella oxytoca (762)0 (0.0)3 (0.4)21 (3.1)440 (60.9)212 (88.7)44 (94.5)30 (98.4)11 (99.9)1 (100.0)14
Other Klebsiella spp. (94)0 (0.0)6 (6.4)21 (28.7)44 (75.5)15 (91.5)6 (97.9)1 (98.9)0 (98.9)1 (100.0)24
Enterobacter cloacae sp. complex (1,978)0 (0.0)16 (0.8)272 (14.6)1057 (68.0)417 (89.1)98 (94.0)63 (97.2)42 (99.3)13 (100.0)28
    Ceftazidime-susceptible Enterobacter cloacae sp. complex (1,356)0 (0.0)13 (1.0)218 (17.0)774 (74.1)264 (93.6)45 (96.9)25 (98.7)12 (99.6)5 (100.0)24
    Ceftazidime-nonsusceptible Enterobacter cloacae sp. complex (622)0 (0.0)3 (0.5)54 (9.2)283 (54.7)153 (79.3)53 (87.8)38 (93.9)30 (98.7)8 (100.0)216
Other Enterobacter spp. (658)0 (0.0)1 (0.2)0 (0.2)0 (0.2)19 (3.0)167 (28.4)335 (79.3)79 (91.3)21 (94.5)22 (97.9)12 (99.7)2 (100.0)24
Citrobacter spp. (816)0 (0.0)4 (0.5)139 (17.5)282 (52.1)249 (82.6)93 (94.0)29 (97.5)12 (99.0)6 (99.8)2 (100.0)14
Proteus mirabilis (PM) (949)0 (0.0)4 (0.4)10 (1.5)44 (6.1)169 (23.9)372 (63.1)259 (90.4)91 (100.0)1632
Indole-positive Proteus spp. (846)0 (0.0)8 (0.9)42 (5.9)189 (28.3)281 (61.5)164 (80.9)93 (91.8)69 (100.0)832
Serratia marcescens (1,221)0 (0.0)15 (1.2)274 (23.7)687 (79.9)170 (93.9)30 (96.3)30 (98.8)15 (100.0)48
Other Serratia spp. (71)0 (0.0)1 (1.4)4 (7.0)15 (28.2)18 (53.5)27 (91.5)5 (98.6)1 (100.0)24
Salmonella spp. (204)0 (0.0)1 (0.5)2 (1.5)56 (28.9)36 (46.6)87 (89.2)18 (98.0)2 (99.0)2 (100.0)24
Acinetobacter baumannii-Acinetobacter calcoaceticus sp. complex (2,101)0 (0.0)23 (1.1)150 (8.2)137 (14.8)186 (23.6)275 (36.7)642 (67.3)509 (91.5)149 (98.6)23 (99.7)6 (>99.9)1 (100.0)24
Other Acinetobacter spp. (292)1 (0.3)1 (0.7)13 (5.1)69 (28.8)67 (51.7)27 (61.0)28 (70.5)32 (81.5)41 (95.5)13 (100.0)0.254
Pseudomonas aeruginosa (2,630)0 (0.0)1 (<0.1)2 (0.1)18 (0.8)18 (1.5)33 (2.7)118 (7.2)687 (33.3)843 (65.4)910 (100.0)32>32
Stenotrophomonas maltophilia (604)0 (0.0)2 (0.3)22 (4.0)87 (18.4)236 (57.5)146 (81.6)77 (94.4)26 (98.7)7 (99.8)1 (100.0)28
Haemophilus influenzae (3,383)1 (<0.1)7 (0.2)106 (3.4)1512 (48.1)1509 (92.7)224 (99.3)18 (99.8)6 (100.0)11
    β-Lactamase-positive Haemophilus influenzae (736)0 (0.0)18 (2.4)292 (42.1)371 (92.5)52 (99.6)3 (100.0)11
    β-lactamase-negative Haemophilus influenzae (2,647)1 (<0.1)7 (0.3)88 (3.6)1220 (49.7)1138 (92.7)172 (99.2)15 (99.8)6 (100.0)11
Moraxella catarrhalis (1,226)174 (14.2)782 (78.0)225 (96.3)40 (99.6)5 (100.0)0.120.25