Table 3.

Gene copy number and sequence analysis ofpfmdr1 alleles from isolates of P. falciparumfrom the western border of Thailand

IsolateMefloquine concn (ng/ml)pfmdr1 copy no.Amino acid at codona:
86184103410421246
158.82.0AsnTyrSerAsnAsp
288.61.0AsnTyrSerAsnAsp
343.31.5AsnPheSerAsnAsp
472.73.0AsnPheSerAsnAsp
569.31.0AsnTyrSerAsnAsp
624.70.5TyrTyrSerAsnAsp
711.40.9AsnPheSerAsnAsp
834.70.9AsnTyrSerAsnAsp
963.72.4AsnTyrSerAsnAsp
10157.91.1AsnPheSerAsnAsp
1168.00.5AsnPheSerAspAsp
1236.11.0AsnTyrSerAsnAsp
1398.11.2AsnTyrSerAsnAsp
148.62.8AsnTyrSerAsnAsp
1528.31.0AsnTyrSerAsnAsp
1665.72.3AsnTyrSerAsnAsp
1779.31.0AsnTyrSerAsnAsp
1832.30.6AsnTyrSerAsnAsp
198.10.4AsnPheSerAspAsp
208.01.3TyrTyrSerAsnAsp
214.71.0TyrTyrSerAsnAsp
228.40.6TyrTyrSerAsnAsp
2342.71.6AsnTyrSerAsnAsp
2413.00.7AsnTyrSerAsnAsp
25183.01.6AsnTyrSerAsnAsp
2658.31.0AsnPheSerAsnAsp
277.21.0AsnPheSerAsnAsp
2838.30.6AsnPheSerAsnAsp
2915.81.0TyrTyrSerAspAsp
30137.31.6AsnTyrSerAsnAsp
3139.91.5AsnTyrSerAsnAsp
3271.11.3AsnPheSerAsnAsp
33111.74.1AsnTyrSerAsnAsp
3485.92.0AsnTyrSerAsnAsp
3517.42.6AsnPheSerAsnAsp
3646.50.5AsnTyrSerAsnAsp
3763.91.3AsnPheSerAsnAsp
3860.91.0AsnTyrSerAsnAsp
39115.43.8AsnTyrSerAsnAsp
4030.95.7AsnTyrSerAsnAsp
419.10.7AsnTyrCysAsnAsp
425.00.6AsnTyrSerAsnAsp
43179.10.5AsnTyrSerAsnAsp
4413.60.4AsnPheSerAsnAsp
45136.40.6AsnTyrSerAsnAsp
4613.30.5AsnPheSerAsnAsp
478.80.4AsnPheSerAsnAsp
4812.30.6AsnTyrSerAsnAsp
49141.31.8AsnTyrSerAsnAsp
509.61.0TyrTyrSerAsnAsp
5115.31.7AsnPheCysAspAsp
5217.50.9AsnPheSerAsnAsp
5365.62.2AsnPheSerAsnAsp
5494.23.5AsnPheSerAsnAsp
  • a Codon mutations are highlighted in boldface type.