Table 1.

rRNA methylase genes involved in MLSB resistance

ClassProteinGene nameGene(s) included% HomologyPlasmid transposoncGenBank no. or referencee
DNAAmino acid
AErm(A)erm(A)erm(A)8381Tn554X03216
erm(TR)AF002716
BErm(B)erm(B)erm(AM)98–10098–100Tn1545X52632
erm(AM)pAMβ-1Y00116
erm(AM)pAM77K00551
erm(B)Tn917M36722
erm(B)pAD2M11180
erm(B)pIP501X72021
erm(AMR)U86375
erm(BC)pIP1527M19270
erm(P),erm(BP)apIP402U18931
erm(IP)pIP501U00453
erm(Z), erm(BZ1),erm(BZ2)aTn5398AF109075
ermpLEM3U48430, X82819
erm(2)pBT233, pMD101X64695,X66468
CErm(C)erm(C)erm(C)99–10098–100pE194J01755,V01278
erm(C)pT48M19652
erm(C)pE5M17990
erm(C)pJR5L04687
erm(C)pA22X54338
erm(C)pSES6X82668
erm(C)pSES5Y09001
erm(C)pSES4aY09002
erm(C)pSES21Y09003
erm(C)J3356::pOX7U36911
erm(IM)pIM13M13761
erm(M)pNE131M12730
erm(M)pPV141U82607
erm(M)pPV142AF019140
DdErm(D)erm(D)erm(D)97–99 97–99 pBD90M29832
erm(J)pBA423L08389
erm(K)M77505
EErm(E)erm(E)erm(E)9996pUC31, pIJ43X51891
erm(E2)M11200
FErm(F)erm(F)erm(F)98–10097–100pBF4M14730
erm(F)Tn4351M17124
erm(FS)pBI106, Tn4551M17808
erm(FU)ChromosomalM62487
GErm(G)erm(G)erm(G)9999pBD370M15332
erm(G)Tn7853L42817
HbErm(H)erm(H)car(B)pOJ159P13079,M16503
IbErm(I)erm(I)mdm(A)34
NbErm(N)erm(N)tlr(D)X97721
ObErm(O)erm(O)lrm8484pLST391M74717
srm(A)AJ223970
QErm(Q)erm(Q)erm(Q)ChromosomalL22689
RErm(R)erm(R)erm(R)M11276
SbErm(S)erm(S)erm(SF)100100pET23M19269
tlr(A)P45439
TbErm(T)erm(T)erm(GT)pGT633M64090
UbErm(U)erm(U)lmr(B)pPZ303X62867
VbErm(V)erm(V)erm(SV)U59450
WbErm(W)erm(W)myr(B)M77505,P43433
XbErm(X)erm(X)erm(CD),erm(A)b99–10099–100pNG2M36726,X51472
erm(CX)Tn5432U21300
YbErm(Y)erm(Y)erm(GM)pMS9757
ZbErm(2)erm(2)srm(D)69
UnclassifiedclrpJI70218
  • a When two or three gene names are listed under “Genes included,” it means that the same gene was designated by two or three different names in the literature; forerm(B), erm(C), and erm(M), multiple related genes have been sequenced, and a selection of these are listed, although they are not complete lists, since some of them have not been completely sequenced.

  • b Newly designated classes, proteins, and genes given a single-letter designation rather than the two-letter or different three-letter designations currently used in the literature.

  • c The list of plasmids includes both recombinant and natural plasmids.

  • d Class D includes genes labeled in the literature as erm(D), erm(J), anderm(K); because they share between 97 and 99% DNA and amino acid homology, they have been grouped under class D anderm(D).

  • e Information was provided by GenBank and references 10-12, 18, 25, 29, 31, 32, 34, 35, 37, 38, 42, 46, 55-57, 60-62, 65, 69, 71, 77, 88, 89, 91, 95, and108-110.