Table 1.

PD endpoints for evernimicin

OrganismAUC/MIC ratio
Stasis targetLog drop targeta90% Emaxtarget
S. pneumoniae115.7239.41,716.4
S. aureus163.4330.1830.8
E. faecalis59.685.4764.4
  • ↵a Log drop targets are a 3-log10-unit decline in the number of CFU per milliliter from pretreatment number at the primary infection site for S. pneumoniae, a 2-log10-unit decline for S. aureus, and a 1-log10-unit decline for E. faecalis.