Table 4.

Effect of MC-207,110 on susceptibility to levofloxacin in the strains containing the target-based mutations

StrainGenotypeMexAB-OprM statusLevofloxacin MIC (μg/ml) with:
No additionMC-207110 at 20 μg/ml
PAM1020Wild typeWild type0.1250.008
PAM1548 gyrA(Thr83→Ile)Wild type10.125
PAM1032 nalB Overexpressed20.03
PAM1573 nalB gyrA(Thr83→Ile)Overexpressed80.25
PAM1582 nalB gyrA (Thr83→Ile) parC(Ser87→Leu)Overexpressed321
PAM1667 mexA-phoA::Tc gyrA(Thr83→Ile) parC (Ser87→Leu)Wild type40.25
PAM1609 nalB gyrA (Thr83→Ile) parC(Ser87→Leu) gyrA(Asp87→Tyr)Overexpressed1284
PAM1669 mexA-phoA::Tc gyrA (Thr83→Ile)parC (Ser87→Leu) gyrA (Asp87→Tyr)Wild type81
PAM1619 nalB gyrA (Thr83→Ile)parC (Ser87→Leu) XOverexpressed1,02432