TABLE 4

Factors associated with treatment outcome

FactorOutcomea:ORb (95% CI)P value for ORaOR (95% CI)P value for aOR
FavorableUnfavorable
Sex
    Male1,056 (64.1)235 (89)4.54 (3.05–6.76)<0.0011.92 (1.02–3.62)0.043
    Female592 (35.9)29 (11)ReferenceReference
Age (yr)
    18–591,519 (92.2)235 (89)Reference0.085NScNS
    ≥60129 (7.8)29 (11)1.45 (0.95–2.22)NSNS
Smoker
    No1,172 (71.1)128 (48.5)Reference<0.001NSNS
    Yes476 (28.9)136 (51.5)2.62 (2.01–3.41)NSNS
Alcohol user
    No1,077 (65.4)93 (35.2)Reference<0.001Reference<0.001
    Yes571 (34.6)171 (64.8)3.47 (2.64–4.55)2.17 (1.42–3.31)
Smear statusd
    Negative515 (42.4)59 (24)Reference<0.001NSNS
    Positive700 (57.6)187 (76)2.33 (1.7–3.19)NSNS
Diabetes
    No1,251 (75.9)209 (79.2)Reference0.248NSNS
    Yes397 (24.1)55 (20.8)0.83 (0.6–1.14)NSNS
Baseline INH susceptibilitye
    Sensitive687 (96.5)147 (84)Reference<0.001Reference<0.001
    Resistant25 (3.5)28 (16)5.23 (2.97–9.24)5.74 (3.12–10.59)
Body wt (kg)49 (42–56)45 (40–50)0.96 (0.95–0.97)<0.0010.96 (0.94–0.98)<0.001
Disease
    EPTB637 (38.7)34 (12.9)Reference<0.001NSNS
    PTB1,011 (61.3)230 (87.1)4.26 (2.93–6.19)NSNS
Category
    I1,464 (88.8)195 (73.9)Reference<0.001Reference<0.001
    II184 (11.2)69 (26.1)2.82 (2.06–3.86)2.39 (1.56–3.65)
Concn (μg/ml) at 2 h postdosing
    RMP2.3 (0.7–5)2.1 (0.5–4.4)0.97 (0.93–1.01)0.1400.94 (0.89–0.99)0.036
    INH7.4 (4.5–10.9)8.4 (4.7–11.8)1.02 (0.99–1.05)0.116NSNS
    PZA33.3 (24–41.5)35.8 (23.7–42.5)0.99 (0.98–1.01)0.726NSNS
  • a Data represent the number (percent) of patients for all factors except body weight and the concentration at 2 h postdosing, for which the data represent the median (IQR).

  • b OR, odds ratio.

  • c NS, not significant.

  • d Data are only for pulmonary TB patients (n = 1,241).

  • e Data are only for culture-positive cases (n = 651).