TABLE 1

Predicted mean malaria incidences per year for each dosing scenario at different adherence levels

Dosing scheduleaScenarioYearly malaria incidence (%) at various adherence levels
(A: 100%)(B: 80%)(C: 60%)(D: 60% + 30% IIV)
Monthly maintenance1: No loading dose2.65.410.410.1
2: One loading dose2.44.89.410.2
3: Two loading doses2.14.510.49.4
Weekly maintenance (three tablets)4: No loading dose0.31.24.54.7
5: One loading dose0.21.13.74.3
6: Two loading doses0.20.93.23.9
7: Three loading doses0.20.82.83.7
8: Four loading doses0.20.83.13.4
Weekly maintenance (two tablets)9: No loading dose0.73.28.49.3
10: One loading dose0.62.57.78.4
11: Two loading doses0.62.27.67.8
12: Three loading doses0.31.33.84.2
13: Four loading doses0.31.24.54.0
  • a Details for each specific dosing are specified in Fig. 1. Scenario numbers correspond to those listed in Fig. 1.