Table 1.

Estimated compartmental pharmacokinetic parameters of caspofungin in plasmaa

Drug dose (mg/kg)Cmax (μg/ml)Cmin (24 h) (μg/ml)AUC0–∞ (μg/ml · h)Vss (liter/kg)CL (liter/h/kg)t1/2αb(h)t1/2β(h)t1/2γ (h)
Single dose
 120.02 ± 1.180.00 ± 0.0020.57 ± 0.890.239 ± 0.0110.050 ± 0.0020.09 ± 0.002.00 ± 0.0631.61 ± 0.12
 360.47 ± 8.490.00 ± 0.0047.14 ± 3.600.277 ± 0.0330.068 ± 0.0050.05 ± 0.001.84 ± 0.0730.23 ± 1.19
 6123.40 ± 5.170.10 ± 0.00119.30 ± 10.910.275 ± 0.0060.053 ± 0.0060.11 ± 0.011.85 ± 0.1426.19 ± 1.29
Multiple dose
 116.01 ± 0.610.00 ± 0.0013.15 ± 2.370.299 ± 0.0110.086 ± 0.0170.09 ± 0.011.62 ± 0.2131.87 ± 0.18
 351.05 ± 4.590.18 ± 0.1863.70 ± 21.340.378 ± 0.0500.065 ± 0.0150.09 ± 0.012.20 ± 0.3734.77 ± 3.09
 6105.52 ± 8.920.63 ± 0.26158.43 ± 15.580.351 ± 0.0160.043 ± 0.0040.10 ± 0.003.53 ± 0.4830.86 ± 0.96
  • a All values represent the means ± standard errors of the means of values three rabbits each. Abbreviations: Cmin(24 h), plasma concentration at the end of the dosing interval (24 h);t1/2α distributional half-life;t1/2β, apparent elimination half-life;t1/2γ, terminal elimination half-life.

  • b P ⩽ 0.05 for the comparison among dosage groups by ANOVA.