Table 5.

Inhibition of carbapenem-hydrolyzing β-lactamases from Acinetobacter isolates

IsolateIC50(μM)a for
ClavulanateTazobactamEDTA
Not pre-incbPre-inccNot pre-incPre-incNot pre-incPre-inc
327009-Spain1.70.12.00.02>2>2
04737-Belgium0.860.041.60.007>2>2
A-15-Kuwait1.100.11.10.05>2>2
I-16-Singapore1.20.652.50.025>2>2
  • a 50% inhibitory concentration.

  • b Not pre-inc, enzyme and inhibitor not preincubated together before addition of substrate.

  • c Pre-inc, enzyme and inhibitor preincubated for 10 min at 37°C before the addition of penicillin as the substrate.