Table 2.

Amino acid differences among extended-spectrum oxacillinases compared to OXA-10

OxacillinaseAmino acid(s) at position(s)a:
1020285870–737692110127144–146164167184208216–218240258272
OXA-10IGSDS-T-F-KNVTAY-G-NWGYAK-T-GESE
OXA-M101b L
OXA-M102b S D
OXA-M103b K
OXA-11 S D
OXA-14 D
OXA-16T D
OXA-17 S
OXA-13TSN S SFGNA
OXA-13-1b TSN S S D FGNA
OXA-19TSNS D FGNA
OXA-28TSNS G FGNA
  • a The standard numbering scheme for class D enzymes (DBL numbering) is used (3). The amino acids in boldface may contribute to the extension of the substrate hydrolysis profile, leading to extended-spectrum derivatives.

  • b In vitro-obtained mutant (9).