Table 5.

Activities of Ro 63-9141, vancomycin, and linezolid against experimental s.c. MRSA abscesses in mice

StrainCompoundMIC (mg/liter)Dose (mg/kg i.p.)No. of animalsMedian log-unit no. of CFU at the site of infectionaMedian decrease in log-unit no. of CFU compared to that of the untreated control groupa
MRSA I-6No compound217.42
Ro 63-9141210212.305.12
Vancomycin210214.003.42
Linezolid22056.620.80
S. aureus No compound56.79
Mu50Ro 63-91412105<2>4.79
MRSAVancomycin84056.660.13
VISALinezolid42056.150.64
  • a 72 h after infection.