Table 1.

In vitro activities of Ro 63-9141 and reference compounds

MSSA (19)
 Ro 63-91410.510.25–1
 Cefotaxime242–32
 Cefepime282–16
 Meropenem0.120.120.06–0.25
 Ciprofloxacin0.510.25–>8
 Vancomycin221–2
MRSA (77)
 Ro 63-9141240.5–4
 Cefotaxime>64>64>64   
 Cefepime>32>32>32   
 Meropenem32>32>32   
 Ciprofloxacin0.5>80.12–>8
 Vancomycin121–8
MSSE (19)
 Ro 63-91410.2510.12–1
 Cefotaxime140.25–4
 Cefepime0.520.25–4
 Meropenem0.1210.12–4
 Ciprofloxacin0.250.50.25–>8
 Vancomycin222–4
MRSE (19)
 Ro 63-9141121–4
 Cefotaxime32>648–>64
 Cefepime16>324–>32
 Meropenem16>324–>32
 Ciprofloxacin0.25>80.25–>8
 Vancomycin242–4
Staphylococcus haemolyticus (31)
 Ro 63-9141480.125–8
 Cefotaxime>32>322–>32
 Cefepime>32>321–>32
 Meropenem>32>320.125–>32
 Ciprofloxacin0.5320.25–>32
 Vancomycin241–4
Staphylococcus hominis (28)
 Ro 63-9141440.25–4
 Cefotaxime>32>321–>32
 Cefepime>32>320.5–>32
 Meropenem>32>32≤0.06–>32
 Ciprofloxacin0.510.25–>32
 Vancomycin241–4
Staphylococcus saprophyticus (55)
 Ro 63-91410.250.50.06–4
 Cefotaxime480.5–32
 Cefepime240.5–>32
 Meropenem0.250.50.06–32
 Ciprofloxacin120.25–2
 Vancomycin220.5–2
Staphylococcus sciuri (13)
 Ro 63-91410.520.25–2
 Cefotaxime8>321–>32
 Cefepime4>321–>32
 Meropenem0.5160.25–16
 Ciprofloxacin120.25–2
 Vancomycin221–2
Staphylococcus warneri (10)
 Ro 63-91410.2520.25–4
 Cefotaxime2321–>32
 Cefepime2321–>32
 Meropenem0.2580.25–>32
 Ciprofloxacin0.510.25–1
 Vancomycin221–4
Penicillin-susceptibleStreptococcus pneumoniae (19)
 Ro 63-91410.0150.030.015–0.03
 Penicillin G≤0.06≤0.06 ≤0.06
 Cefotaxime≤0.030.06≤0.03–0.25
 Cefepime0.030.060.03–0.12
 Meropenem0.0150.030.015–0.03
 Ciprofloxacin221–4
 Vancomycin0.510.5–1
Penicillin-resistantStreptococcus pneumoniae (20)
 Ro 63-91410.520.03–2
 Penicillin G1161–>16
 Cefotaxime140.12–4
 Cefepime240.25–4
 Meropenem0.520.06–2
 Ciprofloxacin120.5–4
 Vancomycin0.50.5  0.5 
α-Hemolytic streptococci (21), Streptococcus salivarius (3), Streptococcus sanguis (4), Streptococcus bovis (3),Streptococcus intermedius (2), Streptococcus mitis (3), Streptococcus oralis (2), Streptococcus mutans (3), Streptococcus gordonii(1)
 Ro 63-91410.040.25≤0.008–2
 Cefotaxime0.122≤0.03–8
 Cefepime0.1220.03–8
 Meropenem0.0610.015–4
 Ciprofloxacin241–>8
 Vancomycin110.5–2
β-Hemolytic streptococci (20),Streptococcus pyogenes (10), Streptococcus agalactiae (10)
 Ro 63-91410.030.06≤0.008–0.12
 Cefotaxime0.030.12≤0.03–0.12
 Cefepime0.030.120.03–0.25
 Meropenem0.030.120.015–0.25
 Ciprofloxacin120.5–4
 Vancomycin0.510.25–1
Enterococcus faecalis (14)
 Ro 63-91410.540.25–>32
 Ampicillin241–>32
 Cefotaxime8>324–>32
 Cefepime>32>3232–>32
 Meropenem8324–>32
 Ciprofloxacin2>80.5–>8
 Vancomycin4>322–>32
Enterococcus faecium (16) for which the ampicillin MIC is ≤8μg/ml
 Ro 63-9141481–8
 Ampicillin482–8
 Cefotaxime>32>3216–>32
 Cefepime>32>3232–>32
 Meropenem16>324–>32
 Ciprofloxacin4>82–>8
 Vancomycin4>324–>32
Enterococcus faecium (20) for which the ampicillin MIC is ≥16 μg/ml
 Ro 63-9141>32>328–>32
 Ampicillin>32>3216–>32
 Cefotaxime>32>32>32   
 Cefepime>32>32>32   
 Meropenem>32>32>32   
 Ciprofloxacin>8>88–>8
 Vancomycin4>322–>32
ESBL-negativeEscherichia coli (24)
 Ro 63-91410.060.06≤0.03–0.12
 Cefotaxime0.060.12≤0.03–0.12
 Cefepime≤0.030.06≤0.03–0.5
 Meropenem≤0.030.06≤0.03–0.06
 Ciprofloxacin0.0150.12≤0.008–0.12
ESBL-positiveEscherichia coli (17)
 Ro 63-91414>320.06–>32
 Cefotaxime4320.06–>64
 Cefepime280.06–16
 Meropenem0.060.06≤0.03–0.12
 Ciprofloxacin0.060.25≤0.008–0.25
ESBL-negativeKlebsiella pneumoniae (19)
 Ro 63-9141≤0.060.25≤0.06–1
 Cefotaxime≤0.06≤0.06 ≤0.06
 Cefepime≤0.060.25≤0.06–0.5
 Meropenem≤0.06≤0.06≤0.06–0.1
 Ciprofloxacin≤0.06≤0.06≤0.06–0.25
ESBL-positive Klebsiella pneumoniae (22)
 Ro 63-91414>320.12–>32
 Cefotaxime8640.25–>32
 Cefepime2160.12–32
 Meropenem0.120.250.06–16
 Ciprofloxacin1>80.03–>8
Klebsiella oxytoca (9)
 Ro 63-91410.50.06–>32
 Cefotaxime≤0.03≤0.03–1
 Cefepime≤0.03≤0.03–2
 Meropenem0.06≤0.03–0.12
 Ciprofloxacin0.030.015–0.06
Citrobacter freundii (19)
 Ro 63-9141180.12–8
 Cefotaxime32641–>64
 Cefepime0.52≤0.03–4
 Meropenem0.120.250.06–0.5
 Ciprofloxacin0.030.250.015–0.25
Enterobacter cloacae (25)
 Ro 63-9141480.12–8
 Cefotaxime>64>6416–>64
 Cefepime140.12–8
 Meropenem0.120.250.06–0.25
 Ciprofloxacin0.030.120.015–4
Enterobacter aerogenes (10)
 Ro 63-91410.254≤0.03–8
 Cefotaxime32>320.12–>32
 Cefepime180.06–8
 Meropenem0.12160.06–16
 Ciprofloxacin0.258≤0.03–16
Pantoea agglomerans (10)
 Ro 63-91410.12160.06–16
 Cefotaxime0.128≤0.03–>32
 Cefepime≤0.030.5≤0.03–4
 Meropenem0.060.12≤0.03–0.5
 Ciprofloxacin≤0.032≤0.03–32
Proteus mirabilis (20)
 Ro 63-9141≤0.06≤0.06≤0.06–0.12
 Cefotaxime≤0.06≤0.06≤0.06–0.5
 Cefepime0.120.12≤0.06–0.5
 Meropenem≤0.06≤0.06≤0.06–0.12
 Ciprofloxacin≤0.060.12≤0.06–0.25
Proteus vulgaris (10)
 Ro 63-9141>32>320.25–>32
 Cefotaxime≤0.030.5≤0.03–>32
 Cefepime0.060.25≤0.03–16
 Meropenem0.250.50.25–2
 Ciprofloxacin0.060.120.015–>8
Morganella morganii (15)
 Ro 63-91410.060.12≤0.03–0.12
 Cefotaxime0.068≤0.03–16
 Cefepime0.060.12≤0.03–0.12
 Meropenem0.250.50.25–0.5
 Ciprofloxacin0.06>80.06–>8
Providencia spp. (11), Providencia rettgeri (6), Providentia stuartii (5)
 Ro 63-9141≤0.030.12≤0.03–>32
 Cefotaxime0.124≤0.03–>32
 Cefepime0.250.5≤0.03–>32
 Meropenem0.2510.06–>32
 Ciprofloxacin1>80.03–>8
Enterobacter aerogenes(10)
 Ro 63-91410.254≤0.03–8
 Cefotaxime32>320.12–>32
 Cefepime180.06–8
 Meropenem0.12160.06–16
 Ciprofloxacin0.258≤0.03–16
Serratia marcescens (19)
 Ro 63-9141140.06–>32
 Cefotaxime1320.12–>64
 Cefepime0.510.06–16
 Meropenem0.120.25≤0.03–0.25
 Ciprofloxacin0.25>8≤0.03–>8
Acinetobacter spp. (21), Acinetobacter junii (2), Acinetobacter lwoffii (4),Acinetobacter baumannii (15)
 Ro 63-91418>8≤0.03–>8
 Cefotaxime32>320.5–>32
 Cefepime32>320.12–>32
 Meropenem280.06–8
 Ciprofloxacin4>80.015–>8
Ceftazidime-susceptible Pseudomonas aeruginosa(60)
 Ro 63-91412161–16
 Ceftazidime481–8
 Cefotaxime32>642–>64
 Cefepime4161–16
 Meropenem0.520.25–8
 Ciprofloxacin0.2510.12–>8
Ceftazidime-resistant Pseudomonas aeruginosa(17)
 Ro 63-914116>642–>64
 Ceftazidime16>6416–>64
 Cefotaxime>64>6464–>64
 Cefepime32324–64
 Meropenem2160.5–16
 Ciprofloxacin2>80.5–>8
Vibrionaceae (20), Aeromonas spp. (9), Plesiomonas shigelloides (3), Vibrio cholerae (4), Vibrio parahaemolyticus (4)
 Ro 63-91410.120.50.06–1
 Cefotaxime0.030.25≤0.008–>8
 Cefepime0.120.25≤0.008–0.25
 Meropenem0.030.5≤0.008–2
 Ciprofloxacin0.0150.250.008–0.25
Haemophilus influenzae (18)
 Ro 63-91410.0610.06–1
 Cefotaxime0.0150.250.015–0.5
 Cefepime0.0620.06–2
 Meropenem0.1210.06–1
 Ciprofloxacin0.030.030.015–0.02
Neisseria gonorrhoeae (19)
 Ro 63-91410.030.12≤0.015–0.12
 Cefotaxime0.060.25≤0.015–0.25
Moraxella catarrhalis (18)
 Ro 63-91410.121≤0.008–1
 Cefotaxime0.250.50.06–0.5
 Cefepime0.510.12–1
 Meropenem≤0.008≤0.008≤0.008
 Ciprofloxacin0.120.120.06–0.25
Bacteroides fragilis (21)
 Ro 63-914116320.25–>64
 Cefotaxime16>640.5–>64
 Cefepime64>642–>64
 Meropenem0.120.50.06–2
 Metronidazole0.510.12–>32