Table 2.

MICs for 18 strains of N. gonorrhoeae with altered quinolone resistance with details of phenotype, GyrA and ParC changes, and geographic source

Strain no.YrMICa (μg/ml) of:Typeb (A/S class)Sequence change(s)cGeographic sourced
CIPGRXMXFTVAGyrAParC
119930.120.120.120.03Pro/A6D95NO
219970.120.120.250.03Nr/B4D95GU
319910.120.250.250.12Nr/A4D95NP
419980.250.50.50.06Nr/B3D95NT
519910.50.50.50.12Pro/B8S91FT
619920.50.50.50.25Nr/B3S91YP
71998110.50.12Nr/B4S91FT
8199610.50.50.5Pro/B2S91YE91QC
919972120.12Nr/B6S91F, D95GS88PU
1019972221Nr/A6S91F, D95GD86NP
1119974240.12Nr/B3S91F, D95GS88PA
1219964422Pro/A6S91F, D95GD86NU
1319988421Pro/A6S91F, D95GS87RC
1419988844Nr/A6S91F, D95NE91KC
15199581644Nr/B7S91F, D95GE91K, S87NU
161995163288ProArg/B3S91F, D95GE91K, S87NB
171995163288Nr/B7S91F, D95GE91K, S87NU
181995161682Arg/B4S91F, D95NS87RA
  • a CIP, ciprofloxacin; GRX, grepafloxacin; MXF, moxifloxacin; TVA, trovafloxacin.

  • b Nr, nonrequirer; Pro, proline requirer; Arg, arginine requirer; A/S, auxotype/serotype.

  • c D, aspartate; N, asparagine; G, glycine; S, serine; F, phenylalanine; Y, tyrosine; E, glutamine; Q, glutamate; P, proline; R, arginine; K; lysine.

  • d O, overseas, unknown; U, unknown; P, Philippines; T, Thailand; C, China; A, Australia; B, Bali, Indonesia.