Table 1.

Pharmacokinetic parameters of indinavira

ParameterbValue for:
Children Adults
Indinavir dose (q8h)33 mg/kg of MW 50 mg/kg of MW 67 mg/kg of MW 800 mg
n 19 17 5 15
AUC0–8 (mg/liter · h) 10.5 (2.8–51.0)20.6 (4.1–38.7) 36.6 (27.2–80.0) 19.1 (8.5–33.3)
CL/F [liters/(h · kg)] 1.1 (0.3–4.6)0.9 (0.5–4.7) 0.6 (0.4–1.2) 0.6 (0.4–1.4)
V/F (liters/kg) 2.3 (0.5–11.5) 1.7 (0.5–6.8)1.1 (0.3–1.7) 1.3 (0.6–3.2)
C max(mg/liter) 6.4 (2.1–19.5) 9.7 (2.3–17.0)17.1 (15.0–29.0) 8.7 (3.6–15.8)
T max (h) 1.0 (0.5–2.0)1.0 (0.5–2.5) 0.8 (0.4–1.6) 1.0 (0.5–2.0)
C min (mg/liter) 0.04 (<0.02–0.26)0.07 (0.02–0.21) 0.17 (0.05–0.38)0.13 (0.03–0.29)
  • a Data are median values, with ranges in parentheses.

  • b CL, clearance; F, bioavailability;V, volume of distribution.