Table 1.

Numbering of the important class B residuesa

β-LactamaseZn1 ligandsZn2 ligands
Subclass B1
Consensus BBLHis116His118His196Asp120Cys221His263
 BcIIHis86His88His149Asp90Cys168His210
 IMP-1His77His79His139Asp81Cys158His197
 CcrAHis99His101His162Asp 103Cys181His223
VIM-1His88His90His153Asp92Cys172His214
BlaBHis76His78His139Asp80Cys158His200
IND-1His96His98His159Asp100Cys178His220
Subclass B2
Consensus BBLAsn116His118His196Asp120Cys221His263
CphAAsn69His71His148Asp73Cys167His205
Sfh-IAsn72His74His151Asp76Cys170His212
Subclass B3
Consensus BBLHis/Gln116His118His196Asp120His121His263
 L1His84His86His160Asp88His89His225
FEZ-1His71His73His149Asp75His76His215
GOB-1Gln80His82His157Asp84His85His213
THIN-BHis105His107His185Asp109His110His253
  • a For CcrA, the numbering is reported in references 10 and 24. When not confirmed by a three-dimensional structure, the ligands are underlined. The consensus (bold) and putative consensus (bold and underlined) ligand numbers are given for each subgroup.