Table 2.

Effect of amphotericin B dosing interval on treatment outcome

OrganismDose (95% confidence interval)a
q72hq24hq12h
FD1 log10FD1 log10FD1 log10
C. albicansK-12.33 (1.63–3.03)6.11 (5.41–6.81)2.40 (2.01–2.79)>20, SE 0.56>20, SE 0.05>20, SE 0.05
C. albicans98-171.52 (1.51–1.53)2.32 (2.31–2.33)4.46 (3.56–5.36)10.3 (9.40–11.2)4.81 (4.71–4.91)16.9 (16.8–17.0)
C. albicans98-2340.83 (0.77–0.89)1.57 (1.51–1.63)1.85 (1.68–1.98)2.71 (2.58–2.84)2.00 (1.90–2.10)3.11 (3.01–3.21)
C. krusei58100.47 (0.14–0.80)4.36 (4.03–4.69)1.94 (1.16–2.72)8.01 (7.23–8.32)3.32 (2.70–3.90)>20, SE 0.30
C. dubliniensis35881.18 (0.20–2.16)2.83 (1.85–3.81)3.60 (3.23–3.97)>20, SE 0.80>20, SE 0.05>20, SE 0.05
  • a q72h, every 72 h; FD, fungistatic dose (in milligrams per kilogram per 72 h); 1 log10, 1 log10 kill (in milligrams per kilogram per 72 h).