TABLE 1

Antiviral activity of pibrentasvir in vitro

HCV replicon or virusPibrentasvir EC50 (pM)c
HCV stable replicons in 0% human plasmaa
    GT1a H771.8 ± 0.86
    GT1b Con14.3 ± 1.7
    GT2a JFH-15.0 ± 0.60
    GT2ab2.3 ± 0.65
    GT2b1.9 ± 0.59
    GT3a2.1 ± 0.66
    GT4a1.9 ± 0.61
    GT5a1.4 ± 0.36
    GT6a2.8 ± 0.67
HCV stable replicons in 40% human plasmaa
    GT1a64 ± 14
    GT1b200 ± 54
HIV-1>900,000
HBV>32,000,000
  • a Both the 0% and 40% human plasma assays also contained 5% fetal bovine serum.

  • b The genotype 2a (GT2a) replicon contained M31 in NS5A.

  • c Values are means ± standard deviations. EC50, 50% effective concentration.