Table 3.

Rates of hydrolysis by purified β-lactamases

CompoundMol of substrate hydrolyzed/mol of enzyme/min
Class CClass A
Citrobacter freundii1203Pseudomonas aeruginosa18SHProteus vulgaris1028Staphylococcus aureus PC 1Escherichia coli
TEM1TEM3TEM4
Ro 63-91417.13.65400.9317290460
Ceftriaxone4.16.8900199004,900640
Cephalothin10,00011,00010,0002001,5006,0004,000
Penicillin G9007601,00010,00012,0009,00015,000