Table 2.

Affinity for PBPs

CompoundIC50 for competition with fluorescein-labeled ampicillin (μM)
Staphylococcus epidermidis PBP 2′Enterococcus faecium PBP 5Streptococcus pneumoniae PBP 2xCitrobacter freundii PBP 1b
Ro 63-91410.87>5000.270.16
Ceftriaxone115>5000.160.19
Imipenem>500>5000.162.1
Methicillin>500>5000.05Not tested