Table 2.

Antimicrobial susceptibility patterns of K. pneumoniae 1534, E. coli DH5α clone, and E. coli HB101 transformant

Antimicrobial agent(s) MIC (μg/ml)
K. pneumoniae 1534 (parent) E. coli DH5α E. coli DH5α (pBR322-catI-blaKPC-1) E. coliHB101 transformant containing blaKPC-1E. coli HB101
Imipenem16 ≤0.25 8 8 ≤0.25
Imipenem-clavulanic acida 2 ≤0.250.5 0.5 ≤0.25
Meropenem 16 ≤0.25 4 4≤0.25
Meropenem-clavulanic acid 1 ≤0.25 ≤0.25≤0.25 ≤0.25
Ampicillin >64 2 >64 >644
Amoxicillin-clavulanic acid >32/162/1 >32/16 >32/16 2/1
Piperacillin-tazobactam>128/4 ≤1/4 >128/4 >128/4 ≤1/4
Ceftazidime32 ≤2 8 8 ≤2
Cefoxitin 32 ≤2 1616 4
Cefpodoxime >16 0.5 >16 >16≤0.25
Cefotaxime 64 ≤1 16 8 ≤1
Ceftriaxone >64 ≤1 32 32 ≤1
Aztreonam>64 ≤1 >64 >64 ≤1
Gentamicin >16≤0.25 ≤0.25 ≤0.25 ≤0.25
Tobramycin >16≤0.25 ≤0.25 ≤0.25 ≤0.25
Trimethoprim-sulfamethoxazole >8 ≤0.12 ≤0.12≤0.12 ≤0.12
Chloramphenicol 32 4 >32 44
  • a Clavulanic acid was tested at a fixed concentration of 4 μg/ml.