Table 4.

Mutations in acrR

IsolateAcrA expressionDNA positionCodon substitutionNo. of silent mutationsa
CH5+9188 (ACC→AAC)T5N3
CH10+9209 (ACG→ATG)T12M4
9812 (ACT→ATT)T213I
9815 (AAC→ACC)N214T
CH15+9516 (CCA→CTA)H115Y2
CH19+Δ 9 nt (9383–9391)b IGEL (70–73)→Y
CH21+None0
CH24+None3
CH27+22-nt duplication (9715–9736)FAPQSFDL (78–86) repeated, creating a frameshift1
CH29+9256 (GGG→AGG)G28R0
  • a Changes in nucleotide sequence, with no change in amino acid.

  • b nt, nucleotide.