Table 4.

Posaconazole (SCH56592) MICs for Aspergillusspp. in eight laboratoriesa

Isolate(s) (no. tested) and MIC criterionMIC range (MIC90 or modal MIC)b
RPMIRPMI-2%M3M3-2%
Itraconazole susceptible (12)
 MIC-00.01–0.5 (0.2)0.03–2 (0.2)0.03–0.5 (0.2)0.03–>8 (0.5)
 MIC-20.03–0.12 (0.06)0.008–0.12 (0.06)0.008–0.12 (0.06)0.03–0.06 (0.06)
Itraconazole resistant (isolate no. 5)
 MIC-00.2–1 (1)0.2–2 (0.5)0.5–2 (0.5)0.2–2 (0.5)
 MIC-20.03–0.5 (0.2)0.03–0.2 (0.12)<0.008–0.5 (0.5)<0.008–0.5 (0.2)
Itraconazole resistant (isolate no. 6)
 MIC-00.2–1 (0.5)0.2–1 (0.5)0.12–2 (1)0.12–>8 (0.5)
 MIC-20.06–0.5 (0.12)0.01–0.2 (0.12)0.01–1 (0.2)0.03–0.5 (0.2)
Voriconazole-resistant mutant
 MIC-00.12–>8 (0.2)0.06–2 (0.12)0.5–8 (0.5)0.12–2 (0.2)
 MIC-20.03–0.12 (0.06)0.03–1 (0.03)0.03–0.12 (0.03)0.03–0.06 (0.03)
  • a Species tested were A. fumigatus ( n = 9 ), A. flavus( n = 3 ), and A. terreus ( n = 3 ); see Table 1 for reported data regarding isolates 5 and 6; 48-h MICs are shown.

  • b MICs are reported in micrograms per milliliter; the MIC90 is reported for susceptible isolates and the model MIC is reported for single resistant isolates.