Table 6.

Voriconazole MICs for Aspergillus spp. in eight laboratoriesa

Isolate(s) (no. tested) and MIC criterionMIC range (MIC90 or modal MIC)b
RPMIRPMI-2%M3M3-2%
Itraconazole susceptible (12)
 MIC-00.12–2 (1)0.2–2 (1)0.5–8 (4)0.2–>8 (4)
 MIC-20.01–2 (0.5)<0.008–1 (1)<0.008–1 (1)0.12–1 (0.5)
Itraconazole resistant (isolate no. 5)
 MIC-00.2–0.5 (0.2)0.2–0.5 (0.2)0.2–2 (0.5)0.2–1 (0.5)
 MIC-2 (0.12)0.03–0.2 (0.12)0.03–0.2 (0.06)<0.008–0.2 (0.12)0.03–0.12 (0.12)
Itraconazole resistant (isolate no. 6)
 MIC-01–2 (1)0.5–2 (1)2–4 (4)2–8 (2)
 MIC-20.12–0.5 (0.5)0.12–1 (0.2)0.5–2 (1)0.2–1 (0.5)
Voriconazole-resistant mutant (1)
 MIC-02–>8 (4)2–8 (4)4–>8 (8)4–>8 (8)
 MIC-20.5–4 (0.5)0.2–1 (1)0.2–2 (0.5)0.2–1 (0.5)
  • a Species tested were A. fumigatus ( n = 9 ), A. flavus( n = 3 ), and A. terreus ( n = 3 ); 48-h MICs are shown.

  • b MICs are reported in micrograms per milliliter; the MIC90 is reported for susceptible isolates and the modal MIC is reported for single resistant isolates.