Table 3.

Itraconazole MICs for Aspergillus spp. in eight laboratoriesa

Isolate(s) (no. tested) and MIC criterionMIC range (MIC90 or modal MIC)b
RPMIRPMI-2%M3M3-2%
Itraconazole susceptible (12)
 MIC-00.03–2 (1)0.03–4 (0.5)0.06–>8 (1)0.06–>8 (2)
 MIC-20.01–1 (0.2)<0.008–0.5 (0.12)<0.008–1 (0.2)0.01–1 (0.2)
Itraconazole resistant (isolate no. 5)
 MIC-08–>8 (>8)8–>8 (>8)2–>8 (>8)2–>8 (>8)
 MIC-20.06–>8 (2)0.06–>8 (1)<0.008–>8 (1)<0.008–>8 (1)
Itraconazole resistant (isolate no. 6)
 MIC-01–>8 (>8)1–>8 (>8)2–>8 (>8)1–>8 (>8)
 MIC-20.12–>8 (1)0.12–>8 (0.5)1–>8 (1)0.2–>8 (1)
Voriconazole-resistant mutant (1)
 MIC-00.5–>8 (2)0.5–>8 (0.5)1–>8 (>8)1–>8 (>8)
 MIC-20.06–0.5 (0.2)0.03–0.5 (0.12)0.06–0.5 (0.2)0.01–0.2 (0.06)
  • a Species tested were A. fumigatus ( n = 9 ), A. flavus( n = 3 ), and A. terreus ( n = 3 ); see Table 1 for reported data regarding isolates 5 and 6; 48-h MICs are shown.

  • b MICs are reported in micrograms per milliliter; the MIC90 is reported for susceptible isolates and the modal MIC is reported for single resistant isolates.